Skin of Psoriasis Patients Protects Itself from Viral Infections
Universitatsmedizin Berlin recently discovered why psoriasis patients are less susceptible to viral infections than patients with atopic dermatitis, or atopic eczema.
Psoriatic skin contains a larger quantity of special proteins, which inhibit viral replication. Dr. Robert Sabat’s interdisciplinary team of the Department of Dermatology and the Institute of Medical Immunology discovered a new function of the immune system during a study, published in the journal Science Translational Medicine in collaboration with the Institute of Virology and the Berlin-Brandenburg Center for Regenerative Therapies (BCRT).
A Widespread Ailment
Over 40 million people in the United States and European Union alone suffer from psoriasis and atopic dermatitis, the two most common chronic diseases of the skin. These conditions cause persistent visible changes of the skin that severely impact the patients’ quality of life.
The damaged skin barrier in these patients allow pathogens like viruses to penetrate the skin and multiply, but only atopic dermatitis patients show a high incidence of cutaneous viral infections, which exacerbate the condition and could be life-threatening.
The study’s authors found that atopic dermatitis patients produce smaller amounts of the antiviral proteins that inhibit viral replication than psoriasis patients did. The research team discovered that the immune messenger interleukin-29 triggered these differences in protein production in the two skin diseases.
“Of the thirty messengers produced by the immune cells that we examined in psoriatic skin, we only found a correlation with the quantities of antiviral proteins for interleukin-29,” Dr. Kerstin Wolk of the Institute of Medical Immunology at the Charite, one of the study’s two first authors, told Science Daily. “In fact, interleukin-29 is present in psoriatic skin, but not in affected skin of atopic dermatitis patients.”
Manipulating the Cells
Removing immune protein from psoriasis patients’ skin samples diminishes the quantity of antiviral proteins in the samples. Experiments with healthy skin, skin models and isolated cells from the skin’s upper layer displayed that interleukin-29 can stimulate the production of antiviral proteins, protecting skin cells from viral infection.
Researchers also found that a specific population of immune cells, called Th17 cells, produce interleukin-29. They simultaneously discovered a new function of the immune system.
“These cells promote the production of antiviral proteins and thus, anti-viral defenses in the skin cells,” Dr. Katrin Witte of the Institute of Medical Immunology at the Charite, the study’s first author, told Science Daily.
“It is conceivable that the therapeutic administration of interleukin-29 or substances that mimic its effects could increase patients’ local defenses against viruses,” Dr. Robert Sabat, Head of the Psoriasis Research and Treatment Center at the Charite, told Science Daily. “This would be applicable not only for atopic dermatitis, but also for other chronic inflammatory diseases that take place in epithelia, such as certain lung conditions in which viral infections represent a cofactor. This treatment could alleviate the course of such illnesses.”
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Making Your Own Skin-Essential Rosewater at Home
New Skincare Line Offers a Powerful Solution for Those with Sensitive Skin
7 Simple Dos and Don'ts to Improve Your Skin
Addressing Your Pre-Wedding Skincare Needs
Homemade Recipes for Healthy Hair and Skin
4 Amazing Ingredients to Include in DIY Skincare Treatments
Can You Improve Your Skin by Doing Yoga?
The Benefits of Yogurt for Skin (Internally and Externally)
9 Top Foods for Terrific Skin
The Future of Dermatology Procedures 2017 Scholarship – Healthy Skin Portal
11 Easy Ways to Keep Skin Looking Terrific
Tips for Eating Chocolate and Not Harming Your Skin
Summer Skincare Essential: Face and Body Scrubs
Seven Foods for Terrific Skin
6 Amazing Tricks to Improve Your Skin
What are the Best Treatments for Your Skin?
Are Your Daily Habits Destroying Your Skin?
ASA Offers Up Seven Principles for Healthy Skin
Does the Wrong Mix of Skin Bacteria Cause Acne?
Can Probiotics Help Acne?
How Do Celebrities Keep Their Skin Looking Great?
What Should You Be Eating to Help Your Skin?
7 Korean Beauty Products That You Should Own
It's Time to Get Ready for Great Looking Summer Hair and Skin
Six Skincare Tips from Different Cultures
Top Beauty Tips on a Budget
Three Simple Mistakes That Could Be Ruining Your Skin
Essential Ingredients for a Great Complexion
Six Foods to Help Hydrate Your Skin
New Ideas for Morning Skincare
The Surprising New K-Beauty Super Ingredient: Watermelon
Five Simple Foods to Boost Your Skin
Keeping Your Skin Healthy in the Summer
Top Skincare Tips for Guys
5 Amazing Skincare Products That Are Cruelty-Free
The Best Selling Beauty Product on Amazon Will Surprise You
How Does Stress Impact Your Skin?
4 Acids That Will Actually Help With Your Skin
Want Better Skin? Here Are Six Foods to Help You Get It
What You Need to Do to Keep Great Skin for Life
How Much Skin Should Be Removed With a Mole?
Is Your Pillowcase Destroying Your Skin?
Jessica Alba's Skincare Line
Fall and Winter Skincare for Men
How to Create An Effective Daily Skincare Routine
4 Supplements You Should Be Using for Your Skin
Collagen Powder: The Next Skincare Secret or Another Passing Fad?
How Do You Pick The Right Moisturizer?
7 Ways to Protect Your Skin This Winter
8 Top Smoothie Ingredients for a Radiant Complexion
Five Water-Rich Foods Your Skin Needs
Uncovering the Secret of the Japanese 4-2-4 Cleansing Technique
Avocados: A Very Healthy Fruit
Using Superfood-Enhanced Beauty Products
Six Tips to Avoid Bad Skin Days
New Technology Allows Restoring of Your Own Collagen and Elastin
How to Slow the Skin's Aging Process
Important Supplements for Aging Skin
How Dermatologists Take Care of Their Skin
How Traditional Thanksgiving Foods Affects Your Skin
How to Use Chocolate to Get Better Skin
Simple Life Hacks for Your Skin
Natural Remedies to Keep Your Skin Looking Great This Winter
Organic Skin Care on the Rise
Little-Known Skincare Rules That Everyone Should Follow
Probiotics for Great Skin
A Supermodel's Skincare Secrets
Your Skin-Friendly Grocery List
Could Oil Cleansing Save Your Skin?
Beauty Device Market Set to Rise in Coming Years
How to Keep Your Skin Radiant Even in Winter
Night Cream: The Key to Healthy Winter Skin
Beauty Brands Harnessing the Power of Superfoods
4 Ways Alcohol Damages Your Skin
How Probiotics Help Skin
4 Ways to Maintain Flawless Skin in the Dead of Winter
Microbiome Imbalance in Gut May Lead to Acne
The Best Diet for Terrific Hair and Skin in Winter
Is Coconut The Key to Healthier Skin?
Celebrities Struggle with Acne Too
Six Ways to Improve Your Skin
What You Need for a Skin-Friendly Diet
Five Simple Steps to Healthier Skin
Why Vaseline is Still An Excellent Choice for Skincare
Dermaplaning Myths Debunked
What Are The Best Ways to Deal with Blackheads?
Say Goodbye to Dry Skin
Yoga Can Help Your Skin
Using a K-Beauty Routine to Tackle Eczema
What is Your Skin Barrier and How Can You Protect It?
Five Top Foods for Maintaining Healthy Skin
Little-Known Tricks to Give You Better Skin
How Can Ayurveda Principles Help Your Skin?
Five Foods with Top Beauty Benefits
Get Your Skin Ready for Summer
3D Printing Could Replace Skin Grafts
Adjusting Your Vitamin D Levels During The Summer
Using Orange Peels to Improve Your Skin
Carotenoids: The Secret to Healthy Skin
Your Greatest Ally in the Quest for Flawless Skin: Vitamin C
Japanese Skincare Routine May Outshine Popular Korean Routine
Six Ways to Help Your Skin Beat The Summer Heat
Consume Fruit for Radiant Skin
New Study Shows Importance of Key Enzyme in Skin Diseases
Bad Habits to Break for Great-Looking Skin
Papaya for Skin Care
Five Fun Ways to Get More Watermelon in Your Diet
Busting Skincare Myths
Tips for Achieving Glowing Skin
Giving Your Skin That Alkaline Glow
Vitamin C for Healthy Skin
Using Collagen to Improve Your Skin
What Can Mushrooms Do For Your Skin?
Vitamin E: The Secret to Beautiful Skin
Regular Facials Keep Skin in Top Condition
Top Foods for Glowing Skin
The Power of Magnetic Masks
Five Top Vitamins for Great Hair, Skin and Nails
When to Ditch Old Makeup
What Do Experts Recommend for Your Skin?
Maple Leaf Extract May Prove The Next Anti-Wrinkle Miracle Ingredient
Essential Winter Skin Care
Does Your Skincare Routine Need a Cat-Face Towel? Absolutely!
Six Overnight Skincare Products for Daytime Beauty
How a 22-Year-Old Created an Empire of Vegan Skincare Products
Revolutionary New Process Could Help Regrow Damaged Skin
Cinnamon for Skin Health
Does The Key to Beautiful Skin Lie in Your Gut?
How to Have Truly Healthy Skin
Five Tricks Everyone Should Know to Keep Their Skin Looking Great
The New Three-Minute Skincare Routine
Nine Foods That Improve Skin
Cold Weather Skin Tips
Do You Want Amazing Skin? Here's Your Beverage Guide
Drinking Coffee Can Actually Help With Rosacea
How Hypertension Can Destroy Your Skin