Results Show Skin Drug Can Help Treat Type 1 Diabetes
A recent small trial on United States patients shows that alefacept, a drug primarily used to treat a skin disorder, helps the body produce its own insulin, key for people with type 1 diabetes.
According to the trial’s researchers, whose findings were published in the Lancet Diabetes & Endocrinology, alefacept may be better for treating type 1 diabetes than other treatments since it protects the immune system. About 400,000 people suffer from type 1 diabetes in the United Kingdom, according to BBC News.
Sold as Amevive, alefacept was used to treat psoriasis, a skin condition characterized by the red scaly patches caused by the overproduction of new skin cells, in the United States before the manufacturer withdrew the drug in 2011. The drug was never approved for the European drug market.
Much like type 1 diabetes, psoriasis is an autoimmune disorder that occurs when the immune system attacks healthy skin cells.
In clinical trials of alefacept on psoriasis, the drug attacked specific types of T-cells involved in attacking insulin-producing cells in type 1 diabetes.
Led by a team at Indiana University in Indianapolis, the researchers decided to further investigate if alefacept could have a positive effect on newly diagnosed type 1 patients.
During the trial, 33 patients received weekly injections of the drug for 12 weeks, followed by a break of 12 weeks and another 12 weekly doses. Another 16 participants were given placebo injections on the same schedule.
The trial’s researchers discovered no difference in the pancreas’ ability to produce insulin two hours after eating food, but they did find significant differences between the two groups four hours after eating. The group who had received alefacept were able to preserve insulin while the placebo group’s insulin levels decreased.
After 12 months, the group taking alefacept showed no significant increase in insulin use, while those in the placebo group. The former group also experienced fewer episodes of hypoglycaemia, or low blood glucose levels, common in type 1 diabetes sufferers.
Lead researcher Professor Mark Rigby of Indiana University commented that the trial’s first 12 were encouraging.
“Although the primary endpoint was not met, several key secondary endpoints were significantly different between treatment groups, suggesting that alefacept might preserve pancreas cell function during the first 12 months after diagnosis,” Rigby told BBC News.
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What are the Best Treatments for Your Skin?
Are Your Daily Habits Destroying Your Skin?
ASA Offers Up Seven Principles for Healthy Skin
Does the Wrong Mix of Skin Bacteria Cause Acne?
Can Probiotics Help Acne?
How Do Celebrities Keep Their Skin Looking Great?
What Should You Be Eating to Help Your Skin?
7 Korean Beauty Products That You Should Own
It's Time to Get Ready for Great Looking Summer Hair and Skin
Six Skincare Tips from Different Cultures
Top Beauty Tips on a Budget
Three Simple Mistakes That Could Be Ruining Your Skin
Essential Ingredients for a Great Complexion
Six Foods to Help Hydrate Your Skin
New Ideas for Morning Skincare
The Surprising New K-Beauty Super Ingredient: Watermelon
Five Simple Foods to Boost Your Skin
Keeping Your Skin Healthy in the Summer
Top Skincare Tips for Guys
5 Amazing Skincare Products That Are Cruelty-Free
The Best Selling Beauty Product on Amazon Will Surprise You
How Does Stress Impact Your Skin?
4 Acids That Will Actually Help With Your Skin
Want Better Skin? Here Are Six Foods to Help You Get It
What You Need to Do to Keep Great Skin for Life
How Much Skin Should Be Removed With a Mole?
Is Your Pillowcase Destroying Your Skin?
Jessica Alba's Skincare Line
Fall and Winter Skincare for Men
How to Create An Effective Daily Skincare Routine
4 Supplements You Should Be Using for Your Skin
Collagen Powder: The Next Skincare Secret or Another Passing Fad?
How Do You Pick The Right Moisturizer?
7 Ways to Protect Your Skin This Winter
8 Top Smoothie Ingredients for a Radiant Complexion
Five Water-Rich Foods Your Skin Needs
Uncovering the Secret of the Japanese 4-2-4 Cleansing Technique
Avocados: A Very Healthy Fruit
Using Superfood-Enhanced Beauty Products
Six Tips to Avoid Bad Skin Days
New Technology Allows Restoring of Your Own Collagen and Elastin
How to Slow the Skin's Aging Process
Important Supplements for Aging Skin
How Dermatologists Take Care of Their Skin
How Traditional Thanksgiving Foods Affects Your Skin
How to Use Chocolate to Get Better Skin
Simple Life Hacks for Your Skin
Natural Remedies to Keep Your Skin Looking Great This Winter
Organic Skin Care on the Rise
Little-Known Skincare Rules That Everyone Should Follow
Probiotics for Great Skin
A Supermodel's Skincare Secrets
Your Skin-Friendly Grocery List
Could Oil Cleansing Save Your Skin?
Beauty Device Market Set to Rise in Coming Years
How to Keep Your Skin Radiant Even in Winter
Night Cream: The Key to Healthy Winter Skin
Beauty Brands Harnessing the Power of Superfoods
4 Ways Alcohol Damages Your Skin
How Probiotics Help Skin
4 Ways to Maintain Flawless Skin in the Dead of Winter
Microbiome Imbalance in Gut May Lead to Acne
The Best Diet for Terrific Hair and Skin in Winter
Is Coconut The Key to Healthier Skin?
Celebrities Struggle with Acne Too
Six Ways to Improve Your Skin
What You Need for a Skin-Friendly Diet
Five Simple Steps to Healthier Skin
Why Vaseline is Still An Excellent Choice for Skincare
Dermaplaning Myths Debunked
What Are The Best Ways to Deal with Blackheads?
Say Goodbye to Dry Skin
Yoga Can Help Your Skin
Using a K-Beauty Routine to Tackle Eczema
What is Your Skin Barrier and How Can You Protect It?
Five Top Foods for Maintaining Healthy Skin
Little-Known Tricks to Give You Better Skin
How Can Ayurveda Principles Help Your Skin?
Five Foods with Top Beauty Benefits
Get Your Skin Ready for Summer
3D Printing Could Replace Skin Grafts
Adjusting Your Vitamin D Levels During The Summer
Using Orange Peels to Improve Your Skin
Carotenoids: The Secret to Healthy Skin
Your Greatest Ally in the Quest for Flawless Skin: Vitamin C
Japanese Skincare Routine May Outshine Popular Korean Routine
Six Ways to Help Your Skin Beat The Summer Heat
Consume Fruit for Radiant Skin
New Study Shows Importance of Key Enzyme in Skin Diseases
Bad Habits to Break for Great-Looking Skin
Papaya for Skin Care
Five Fun Ways to Get More Watermelon in Your Diet
Busting Skincare Myths
Tips for Achieving Glowing Skin
Giving Your Skin That Alkaline Glow
Vitamin C for Healthy Skin
Using Collagen to Improve Your Skin
What Can Mushrooms Do For Your Skin?
Vitamin E: The Secret to Beautiful Skin
Regular Facials Keep Skin in Top Condition
Top Foods for Glowing Skin
The Power of Magnetic Masks
Five Top Vitamins for Great Hair, Skin and Nails
When to Ditch Old Makeup
What Do Experts Recommend for Your Skin?
Maple Leaf Extract May Prove The Next Anti-Wrinkle Miracle Ingredient
Essential Winter Skin Care
Does Your Skincare Routine Need a Cat-Face Towel? Absolutely!
Six Overnight Skincare Products for Daytime Beauty
How a 22-Year-Old Created an Empire of Vegan Skincare Products
Revolutionary New Process Could Help Regrow Damaged Skin
Cinnamon for Skin Health
Does The Key to Beautiful Skin Lie in Your Gut?
How to Have Truly Healthy Skin
Five Tricks Everyone Should Know to Keep Their Skin Looking Great
The New Three-Minute Skincare Routine
Nine Foods That Improve Skin
Cold Weather Skin Tips
Do You Want Amazing Skin? Here's Your Beverage Guide
Drinking Coffee Can Actually Help With Rosacea
How Hypertension Can Destroy Your Skin